Computational Modeling of Gene Regulatory Networks — A by Hamid Bolouri PDF

By Hamid Bolouri

This ebook serves as an creation to the myriad computational ways to gene regulatory modeling and research, and is written particularly with experimental biologists in brain. Mathematical jargon is refrained from and motives are given in intuitive phrases. In instances the place equations are unavoidable, they're derived from first ideas or, at least, an intuitive description is equipped. huge examples and a number of version descriptions are supplied to be used in either school room routines in addition to self-guided exploration and studying. As such, the ebook is perfect for self-learning and likewise because the foundation of a semester-long path for undergraduate and graduate scholars in molecular biology, bioengineering, genome sciences, or structures biology.


  • Introduction
  • What Is a procedure, and Why should still We Care?
  • What types Can and can't Predict
  • Why Make Computational versions of Gene Regulatory Networks?
  • Graphical Representations of Gene Regulatory Networks
  • Implicit Modeling through interplay community Maps
  • The Biochemical foundation of Gene Regulation
  • A Single-Cell version of Transcriptional Regulation
  • Simplified versions: Mass-Action Kinetics
  • Simplified versions: Boolean and Multi-valued Logic
  • Simplified types: Bayesian Networks
  • The dating among good judgment and Bayesian Networks
  • Network Inference in Practice
  • Searching DNA Sequences for Transcription issue Binding Sites
  • Model choice Theory
  • Simplified types — GRN country Signatures in Data
  • System Dynamics
  • Robustness Analysis
  • GRN Modules and construction Blocks
  • Notes on info Processing for GRN Modeling
  • Applications of Computational GRN Modeling
  • Quo Vadis

Readership: Undergraduate- and graduate-level experimental biology scholars and researchers and training biologists; computational biology scholars and researchers; scholars and researchers in bioengineering, genome sciences, and similar disciplines.

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Computational Modeling of Gene Regulatory Networks — A Primer by Hamid Bolouri

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